7 Most Popular Dermal Fillers: Benefits and Results

Looking for a quick, non-surgical way to refresh your appearance? Dermal fillers are your answer. These injectable treatments can smooth wrinkles, restore volume, and contour your face - all without surgery. With over 5 million procedures done annually, they’re a top choice for facial rejuvenation. Here’s a breakdown of the 7 most popular fillers and what they’re best for:

• Juvederm: Hyaluronic acid-based, perfect for cheeks, lips, and wrinkles. Results last 6–24 months.

• Restylane: Offers precision for fine lines and volume. Results last 6–18 months.

• Radiesse: Calcium-based, adds volume and stimulates collagen. Great for jawlines and folds, lasting 12–18 months.

• Sculptra: Stimulates collagen for long-term results (up to 4 years). Ideal for deep volume loss.

• Bellafill: A permanent filler for deep creases and acne scars, lasting over 5 years.

• Fat Transfer: Uses your own fat for natural, lasting results. Best for hollow cheeks and temples.

• RHA Collection: Designed for dynamic facial movements, lasting up to 15 months.

Quick Comparison Table

Choosing the right filler depends on your goals, the area being treated, and desired longevity. Consult a qualified provider to find the best option for you.

Restylane vs. Juvederm: The Top 2 Fillers Compared

Understanding Dermal Fillers

Dermal fillers provide a non-surgical way to address signs of aging by restoring volume and enhancing facial features. Each year, over 3 million Americans opt for these treatments[3], making them a popular choice in cosmetic procedures.

As we age, collagen production declines, leading to sagging skin and a hollow appearance. Dermal fillers help tackle these changes by replenishing lost volume and reinforcing facial structure[3].

There are several types of dermal fillers, categorized by their composition:

Different formulations allow for precise treatments tailored to specific facial areas. For example, softer hyaluronic acid fillers work well for lips, while sturdier options like CaHA are ideal for defining cheekbones[4]. Most FDA-approved fillers are temporary, which means adjustments can be made as facial features change over time[2].

The choice of filler depends on the treatment area. Softer fillers are ideal for delicate areas like lips, while firmer ones are better suited for deeper structures, such as the cheeks or jawline[4]. These treatments smooth wrinkles, enhance facial contours, and restore balance[1].

1. Juvederm: Hyaluronic Acid Filler

Juvederm is a well-known FDA-approved dermal filler line that uses hyaluronic acid to restore facial volume and reduce signs of aging [5]. By 2020, more than 2.6 million Juvederm procedures had been performed, making it a popular choice for facial rejuvenation [7].

The treatment is quick, taking between 15 and 60 minutes, with results visible immediately. Its hyaluronic acid gel smooths fine lines and helps improve the appearance of delicate skin [5][6].

The table highlights key details about Juvederm products for specific treatment areas. In March 2024, Allergan gained FDA approval for Juvederm Voluma XC to treat hollowing in the temples. Clinical trials showed that over 80% of patients saw improvement within three months, with 73% maintaining results for up to a year.

Juvederm treatments also include lidocaine to reduce discomfort during the procedure [5]. For the best results, patients should avoid blood-thinning medications and alcohol before treatment [7]. Afterward, they should skip intense physical activity for 24 hours and steer clear of excessive heat and sun exposure [5].

Pricing depends on the product and treatment area, ranging from $625 for Volbella to $749 for Vollure [8]. Results typically last between 6 and 18 months, depending on the product used and individual factors.

Juvederm’s formulation provides natural-looking results. Hyaluronic acid retains water, adding volume and improving skin density. This makes it effective for softening moderate to severe wrinkles while maintaining natural facial expressions.

2. Restylane: Targeted Volume Treatment

Restylane uses NASHA™ and XpresHAn Technology™ to create a gel that works seamlessly with natural facial movements. This filler, made with hyaluronic acid, allows for precise volume adjustments. Results can last anywhere from 6 to 18 months, depending on the specific treatment area and the type of formulation used [10][11].

Formulations like Restylane Volyme are designed to add flexibility and fullness to different facial areas. Lighter, more flexible versions work well for enhancing lips and smoothing out fine lines, while denser gels are better suited for deeper injections, such as in the cheeks or jawline. These options make it easier to customize treatments for individual needs and ensure proper aftercare.

Ideal candidates are healthy individuals over 21 who have realistic expectations. Treatment is not recommended for those who are pregnant, nursing, or dealing with uncontrolled diabetes or bleeding disorders. Before the procedure, avoid blood thinners for a week and skip alcohol for 24 hours. Afterward, avoid makeup for 12 hours and stay away from extreme temperatures for 24–48 hours.

When compared to fillers like Juvederm, Restylane is often a more budget-friendly choice. Its gradual, natural-looking results are especially appealing to younger patients [9].

3. Radiesse: Calcium-Based Filler

Radiesse is different from other fillers because it’s made with calcium hydroxylapatite (CaHA). This FDA-approved filler combines 30% CaHA microspheres with a 70% gel carrier, delivering both instant volume and longer-lasting effects [12]. Unlike hyaluronic acid (HA) fillers, Radiesse not only adds volume but also improves skin over time.

The filler’s structure includes CaHA microspheres, sized between 25 and 45 micrometers, which create a framework that boosts volume and encourages collagen production [12]. Dr. Miriam Hanson, a board-certified dermatologist, explains:

"It works by adding volume under the skin, plumping up and softening the wrinkle... In addition, Radiesse helps to stimulate your own natural collagen. In other words, it will not only make your skin look better, but will keep your skin wrinkle free for much longer than other methods." [15]

Radiesse results typically last 12 to 18 months, making it a popular choice for moderate to severe facial wrinkles and folds. It’s especially useful in areas needing extra support, including:

• Nasolabial folds

• Marionette lines

• Jawline contouring

• Hand rejuvenation [16][17]

You’ll notice immediate improvements after treatment, with full results developing within 7–10 days as the gel settles and collagen production kicks in [12]. Post-treatment care includes avoiding touching the area for six hours, skipping alcohol for 24 hours, and protecting the skin from UV exposure. Swelling or bruising usually fades within a few days [18].

The manufacturer highlights Radiesse’s unique benefits:

"Radiesse builds your unique structural contours by stimulating collagen and elastin production. Results are immediate, natural, and subtle, for a look that perfectly complements your unique beauty." [13]

Radiesse is particularly effective for areas like the jawline and chin, where added structure and support are often needed [14].

4. Sculptra: Collagen Stimulator

Sculptra is an FDA-approved injectable made from poly-L-lactic acid, designed to smooth wrinkles and stimulate your body’s natural collagen production [19][20]. Administered over a series of sessions spaced 4–6 weeks apart, it works by triggering a controlled inflammatory response, encouraging new collagen formation for results that last [20]. In 2020, 134,123 Sculptra treatments were performed in the United States [19].

Here’s a breakdown of what to expect during the process:

One of the standout features of Sculptra is how long it lasts. While hyaluronic acid fillers typically provide results for 10–12 months, Sculptra can maintain its effects for 2–4 years [21][22]. According to Dr. David Saadat, when mixed and injected correctly, Sculptra is highly adaptable and carries a low risk of vascular complications [21]. Manhattan Aesthetics adds:

"Sculptra® provides an effective, long‐lasting way to restore a youthful appearance" [24].

Sculptra is especially useful for restoring facial volume, addressing temple hollowing, enhancing cheeks, defining the jawline, and even body contouring, including treatments for the buttocks and thighs [21]. To get the best results, it’s important to stay hydrated, avoid intense physical activity for a couple of days post-treatment, and stick to the recommended schedule [19][23]. Over time, the gradual collagen buildup creates natural-looking, long-lasting rejuvenation.

5. Bellafill: Long-Term Results

Bellafill stands out as the only FDA-approved permanent filler, offering results that last over five years. It achieves this by combining bovine collagen for immediate volume with PMMA microspheres that stimulate collagen production over time [25][26][27].

A four-year clinical study revealed that more than 90% of patients were satisfied with procedures like rhinoplasty touch-ups, chin augmentation, and tear trough treatments. Additionally, 99% of participants reported improvement in acne scars [25].

Here’s how Bellafill compares to traditional hyaluronic acid (HA) fillers:

Bellafill is particularly suited for treating:

• Deep facial creases

• Moderate to severe acne scars

• Nasolabial folds

• Chin augmentation

• Cheek enhancement

Its effectiveness is backed by safety data, making it a reliable option for long-term facial rejuvenation.

"Bellafill's special formulation adds immediate volume and helps your body create and keep its own natural volume."
– Bridgetown Aesthetics [25]

However, it’s important to note that a 5-year FDA-mandated post-marketing study found a 1.7% risk of granuloma formation [27]. Dr. Pierone emphasizes:

"Bellafill is a safe and effective long-term filler and has benefits over short-term fillers. That said, it should only be injected by highly experienced facial injectors who understand the potential for rare, but significant late complications."
– Dr. Pierone [27]

Before treatment, patients must undergo an allergy skin test for bovine collagen or lidocaine. Bellafill is approved for individuals aged 21 and older who are looking for a long-lasting solution to facial rejuvenation [25][28].

6. Fat Transfer Fillers

Fat transfer fillers use your own fat to restore facial volume and improve appearance. The process involves taking fat from areas like the abdomen or thighs, processing it, and injecting it into targeted facial areas for a more youthful look [29]. Since some of the fat is naturally reabsorbed by the body, achieving the desired results might require more than one session.

Here’s a quick comparison between fat transfer and synthetic fillers:

Research shows that about half of the injected fat remains long-term [30]. According to the Cleveland Clinic:

"Fat transfer is a safe, minimally invasive procedure that creates natural-looking, youthful results." [29]

Fat transfer fillers are particularly effective for treating:

• Deep volume loss in the face

• Hollow cheeks

• Depressions in the temple area

• Nasolabial folds

• Under-eye hollows

Interestingly, this procedure may also enhance skin quality by encouraging collagen production [31]. However, because some fat is absorbed during the healing process, additional sessions might be necessary [30]. It works especially well in less mobile areas of the face, where fat tends to last longer [32]. While recovery takes longer than with synthetic fillers, the potential for lasting results makes fat transfer a strong option for those seeking long-term facial rejuvenation [31].

This method stands out as a natural and effective choice among the various filler options available.

7. RHA Collection: Dynamic Movement

The RHA (Resilient Hyaluronic Acid) Collection is the first FDA-approved hyaluronic acid filler specifically designed for dynamic wrinkles and folds. Unlike traditional fillers, it’s manufactured at lower temperatures with minimal chemical alteration, preserving the natural structure of hyaluronic acid. This allows it to blend smoothly with facial tissue, delivering results that look natural - even during facial expressions. This approach aligns with today’s aesthetic preferences, which prioritize maintaining natural expressions alongside rejuvenation [35].

Each product in the RHA line is tailored to address specific areas, ensuring results that look natural and move with your face [34].

Dr. Karan Sra of Bayou City Dermatology explains:

"RHA fillers are an effective treatment option to reduce the appearance of wrinkles and folds. They differ from other types of filler because, rather than simply 'filling in the gaps,' they're designed to fill and move naturally along with your facial movements." [37]

The RHA Collection is particularly effective for dynamic facial areas, such as:

• Smile and laugh lines

• Accordion lines

• Lipstick lines

• Corner creases

• Chin creases [36]

These fillers maintain their structure even during significant facial movement [33], with results lasting up to 15 months [37]. However, longevity can vary depending on factors like metabolism, the treated area, and lifestyle habits [38].

For the best outcomes, combine the treatment with good skincare practices, sun protection, and staying hydrated [38]. The RHA Collection’s ability to move naturally with facial expressions while reducing wrinkles makes it a great option for those who want to maintain their expressiveness without sacrificing a smoother, more youthful appearance.

How to Select Your Filler

Choosing the right dermal filler depends on your aesthetic goals, the area being treated, and how long you want the results to last. Here's a guide to help you make an informed choice.

Different fillers are designed for specific purposes. For example, thinner fillers are ideal for smoothing fine lines, while thicker ones are better for restoring deep volume and structure.

The American Board of Cosmetic Surgery (ABCS) emphasizes the importance of choosing the right product for each area:

"Each product is uniquely formulated to have a certain texture, density, and injection depth, which means that certain fillers work better for certain areas of concern." [1]

Before undergoing treatment, consult with a qualified provider. They'll review your medical history, current medications, facial structure, and any potential risks. Factors like skin thickness also play a role - denser fillers often work better for thicker skin, while lighter formulations are more suitable for thinner skin to maintain a natural appearance. Additionally, areas with a lot of muscle movement may require more frequent touch-ups since fillers break down faster in these spots [41][42].

If you're new to fillers, hyaluronic acid-based options are a safe starting point. They offer natural-looking results and can be dissolved if necessary [39]. For those with more experience and a clear idea of their desired look, longer-lasting options like Bellafill might be worth considering [40].

Finally, think about the ongoing costs and commitment involved. Use the duration details above to plan for the long-term investment required for your chosen treatment.

Conclusion

Dermal fillers are becoming more advanced and widely sought after, with the global market expected to hit $9 billion by 2030 [44]. This growth reflects the increasing sophistication and variety of treatment options available today.

These fillers cater to a range of aesthetic needs. Hyaluronic acid fillers like Juvederm and Restylane provide natural-looking, reversible results, while longer-lasting options such as Bellafill can maintain effects for up to five years. However, the latter often comes with a higher upfront cost, typically between $1,000 and $1,500 per syringe [43].

Advancements in the field have also improved safety and comfort. For instance, new techniques using smaller needles help minimize pain and downtime. Additionally, next-generation fillers now include skin-boosting ingredients and enhanced formulations, delivering longer-lasting and more natural results [46][47][48].

The key to successful outcomes lies in choosing the right filler and a skilled provider. With nearly 3 million procedures performed annually in the U.S. [45], trends like personalized treatments and eco-friendly materials are paving the way for even more refined results. By combining these innovations with professional expertise, patients can achieve enhancements that look and feel natural.